Confirm the diagnosis and type of diabetes
Determine individualised glycaemic target
Education, support, healthy eating + exercise
Essential at all times throughout duration of diabetes
Start unless contraindicated
Increase to maximal tolerated dose or 2 g per day
The target HbA1c for most patients with type 2 diabetes is < 53 mmol/mol
Preferred 2nd line agents | 3rd line agents | |||||
ADDITIONAL CONSIDERATIONS | SGLT2i† | GLP1RA† | DPPIVi | TZD | SU | Insulin |
Risk of hypoglycaemia | Rare | Rare | Rare | Rare | Yes | Yes |
Mean ↓ in HbA1c (mmol/mol) | 6 - 13 | 15 | 5 - 10 | 15 | 15 | Any |
Independent cardiorenal benefits | Yes | Yes | No | Yes | No | No |
Effect on weight | ↓ | ↓↓ | ↔ | ↑ | ↑ | ↑ |
Funded | SA only* | SA only† | Yes | Yes | Yes | Yes |